In 1752, George Rogers Clark, the son of John Clark and Ann Rogers Clark, was born in the town of Charlottesville, within Albemarle County, Virginia. After leaving Charlottesville, George Rogers Clark grew up in Caroline County, Virginia. George Clark was the older brother of William Clark, whom was part of the Lewis and Clark expedition sanctioned by former President Thomas Jefferson.
In 1728 Caroline County, Virginia was formed from parts of Essex, King and Queen, and King William Counties. The county was named after the wife of King George II, Caroline of Brandenburg-Ansbach, whose father Margrave John Frederick of Brandenburg-Ansbach was a ruler of a German State Cales the Principality of Ansbach.
The author Philip Hamilton lived in a community around Lake Caroline, in the town of Ruther Glen, within Caroline County, Virginia, from 2012 to 2014.